The Verve Solution

The strategy of the Verve Solution is to disrupt the afferent nerves in the collecting system of the kidney with a proprietary RF ablation catheter.

By disrupting the nerves with ablation the result is an immediate lowering of blood pressure and we anticipate seeing an improvement in kidney and heart function.

The Verve Solution treatment path is less invasive using a natural orifice with no blood contact and is urologist friendly.

  • Low risk and can be performed in the office or outpatient setting
  • Duration is less than three minutes.
  • Procedure time is less than twenty minutes

8f sheath over the wire delivery catheter

4 spherical temp sensing electrodes time/temperature algorithm low power RF monopolar generator

Verve kidney with caption 1
Verve kidney with caption 2

Arterial Approach to Verve Solution

Vs Verve Approach
Vs Aterial

Arterial Approach

Ablation of primarily efferent nerves (80-90%) with no disruption of the diseased signal path affecting  the brain, heart and vasculature.

 

 

The Green markers (below) are the afferent nerves as seen in a typical nerve bundle around the renal artery. The red markers are efferent nerves. The afferent nerves make up approx. 10-15% of the total nerve population in this bundle. A 100% successful denervation of this entire bundle would result in 10-15% denervation of the nerves that control blood pressure.

Possible explanation for 30-40% non-responder rate for this approach.

Verve Solution

Ablation of primarily afferent nerves (70-80%) which control blood pressure. Interruption of the signal path from the kidney to the brain will have a collateral effect on the heart, vasculature, and other events such as pain.

The Red markers (below) as shown in the images below are the afferent nerves that line and infiltrate the wall of the renal pelvis. The green markers are the efferent nerves in the renal pelvis. The afferent nerves are in abundance and quite superficial to the treatment zone, less than

1 mm deep. Denervation of only the superficial afferent nerves that control blood pressure in this scenario would result in near complete denervation.

Target Anatomy Aterial
Target Anatomy Verve.