Renal Pelvic Denervation for the
Treatment of Hypertension
What is Hypertension?
Hypertension, or high blood pressure, is a condition where the force of blood pushing against your artery walls is consistently too high. Over time, this can damage your blood vessels and increase your risk of heart attack, stroke, kidney disease, and other serious problems. About 120 million U.S. adults live with hypertension, and an estimated 93 million have uncontrolled hypertension.
What is Renal Pelvic Denervation?
Renal pelvic denervation is a minimally invasive procedure designed to help lower high blood pressure by targeting the nerves in your kidneys that help regulate blood pressure.
Your kidneys help control blood pressure by sending signals through nerves located in and around the renal pelvis - the area of the kidney where urine collects before it flows to the bladder. These nerves can sometimes become overactive, contributing to high blood pressure.
By disrupting or "denervating" these overactive nerves, the procedure can help reduce blood pressure, especially in patients who do not respond well to medication.
Renal pelvic denervation is a minimally invasive procedure designed to help lower high blood pressure by targeting the nerves in your kidneys that help regulate blood pressure.
Your kidneys help control blood pressure by sending signals through nerves located in and around the renal pelvis - the area of the kidney where urine collects before it flows to the bladder. These nerves can sometimes become overactive, contributing to high blood pressure.
By disrupting or "denervating" these overactive nerves, the procedure can help reduce blood pressure, especially in patients who do not respond well to medication.
Caution: Verve RPD™ System is an investigational device not yet cleared for distribution in any country.
What is Hypertension?
Uncontrolled Hypertension
Hypertension, or high blood pressure, is a condition where the force of blood pushing against your artery walls is consistently too high. Over time, this can damage your blood vessels and increase your risk of heart attack, stroke, kidney disease, and other serious problems.
What is Renal Pelvic Denervation?
Renal pelvic denervation is a minimally invasive procedure designed to help lower high blood pressure by targeting the nerves in your kidneys that help regulate blood pressure.
Your kidneys help control blood pressure by sending signals through nerves located in and around the renal pelvis - the area of the kidney where urine collects before it flows to the bladder. These nerves can sometimes become overactive, contributing to high blood pressure.
By disrupting or "denervating" these overactive nerves, the procedure can help reduce blood pressure, especially in patients who do not respond well to medication.
Renal pelvic denervation is a minimally invasive procedure designed to help lower high blood pressure by targeting the nerves in your kidneys that help regulate blood pressure.
Your kidneys help control blood pressure by sending signals through nerves located in and around the renal pelvis - the area of the kidney where urine collects before it flows to the bladder. These nerves can sometimes become overactive, contributing to high blood pressure.
By disrupting or "denervating" these overactive nerves, the procedure can help reduce blood pressure, especially in patients who do not respond well to medication.
Who Might Benefit from
This Procedure?
You may be a candidate for renal pelvic denervation if:
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You have uncontrolled hypertension (blood pressure that stays high despite taking multiple medications).
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You prefer a non-drug treatment approach.
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Medications aren’t enough to control your blood pressure.
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Your doctor finds that your kidney nerves are contributing to your high blood pressure.
This procedure is typically recommended after other treatment options have not been fully effective.
How is the Procedure Performed?
Preparation
You’ll receive sedation or anesthesia.
Access
A thin, flexible tube (catheter) is inserted into the urinary tract much like treating a kidney stone.
Navigation
The catheter is guided to the renal pelvis (Kidney) using X-ray or ureteroscope imaging.
Denervation
A special device delivers controlled energy (radiofrequency) to the nerve fibers, deactivating them without damaging the kidney tissue.
Completion
The treatment catheter is removed, and you’ll be monitored during a short recovery period.
The whole procedure takes less than 30 minutes and doesn't require major surgery.
Your doctor will carefully assess your risk and make sure the benefits outweigh any potential complications.
Potential Benefits
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May help lower blood pressure when medications alone are not enough.
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No permanent implant required.
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Short recovery time — most people return to normal activity within 1–2 days.
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May reduce medication needs over time (ongoing research).
Are There Any Risks?
As with any medical procedure, renal pelvic denervation (RPD) carries potential risks. Some of the more common or previously observed risks include:
• Mild bleeding related to catheter insertion
• Short-term back or flank pain
• Urinary tract infection
• Temporary protein in the urine (proteinuria)
• Incomplete response to treatment
Other potential, but less common, risks may include:
• Injury to the urinary tract or kidney
• Difficulty urinating
• Worsening of kidney function
• Anemia
• Other unforeseen risks
Your doctor will review your health condition and discuss all possible risks and benefits with you before determining whether this procedure is appropriate for you.
What Happens After the Procedure?
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As an outpatient procedure you may go home the same day.
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Most people return to normal activities in 1–2 days.
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Your doctor will monitor your blood pressure over the next several weeks.
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You may still need to take some medications, but possibly at reduced doses.
TUSK Clinical Trial Results
Published in Hypertension 2022
Pre-Treatment
Post-Treatment
How Effective is It?
Clinical studies have shown that renal pelvic denervation can significantly lower blood pressure in certain patients. However, results vary, and ongoing research is still confirming the long-term benefits.
It can be a powerful tool in combination with lifestyle changes and medication.
TUSK Clinical Trial Results
Published in Hypertension 2022
Pre-Treatment
Post-Treatment
How Effective is It?
Clinical studies have shown that renal pelvic denervation can significantly lower blood pressure in certain patients. However, results vary, and ongoing research is still confirming the long-term benefits. (1)
It can be a powerful tool in combination with lifestyle changes and medication.
Explore the Clinical Trial
Renal pelvic denervation offers a promising option for patients with difficult-to-control high blood pressure. If you’ve struggled to manage your hypertension with medication and lifestyle changes alone, this procedure may offer new hope. Please complete the following survey to determine if you are a candidate for the clinical trial
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